GLYCATED HEMOGLOBIN PRODUCTS

The measurement of glycated hemoglobin as a percentage of total hemoglobin provides a valuable means of assessing the long-term control of glucose levels in diabetic patients and constitutes an important risk indicator for identifying Type 1 and Type 2 diabetes.

There are a number of different human hemoglobin (Hb) variants the most prevalent being HbA1, HbS and HbC.   HbA1 is the most common variant making up approximately 97% of the total hemoglobin in normal adult red blood cells.   HbS is a hemoglobin variant associated with sickle cell anemia which occurs predominantly in African Americans.   HbC is another hemoglobin variant found in people of African ancestry including African Americans and West Indians.  

Glycated hemoglobin is formed in-vivo by the reaction between glucose and the N-terminal region of the hemoglobin b-chain resulting in HbA_1c, HbS_1c or HbC_1c  depending on the predominant hemoglobin variant present.  When developing an assay to detect glycosylation of hemoglobin one should therefore take into account the characteristics of the patient population

We also have the following products available which are intended for spiking for preparation of HbA_1c controls and calibrators.

¨ HbA_1c Solution > 25%, Code AJ 3128-b

¨ HbA_1c  Solution < 4%, Code AJ 3182

Click on the links to see product datasheets.